Krüppel-like factor 6–mediated loss of BCAA catabolism contributes to kidney injury in mice and humans

Altered cellular metabolism in kidney proximal tubule (PT) cells plays a critical role in acute kidney injury (AKI). The transcription factor Krüppel-like factor 6 (KLF6) is rapidly and robustly induced early in the PT after AKI. We found that PT-specific Klf6 knockdown (Klf6(PTKD)) is protective ag...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Piret, Sian E., Guo, Yiqing, Attallah, Ahmed A., Horne, Sylvia J., Zollman, Amy, Owusu, Daniel, Henein, Justina, Sidorenko, Viktoriya S., Revelo, Monica P., Hato, Takashi, Ma’ayan, Avi, He, John Cijiang, Mallipattu, Sandeep K.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201852/
https://ncbi.nlm.nih.gov/pubmed/34074766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024414118
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