Podocyte-Specific Induction of Krüppel-Like Factor 15 Restores Differentiation Markers and Attenuates Kidney Injury in Proteinuric Kidney Disease

BACKGROUND: Podocyte injury is the hallmark of proteinuric kidney diseases, such as FSGS and minimal change disease, and destabilization of the podocyte’s actin cytoskeleton contributes to podocyte dysfunction in many of these conditions. Although agents, such as glucocorticoids and cyclosporin, sta...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Guo, Yiqing, Pace, Jesse, Li, Zhengzhe, Ma’ayan, Avi, Wang, Zichen, Revelo, Monica P., Chen, Edward, Gu, Xiangchen, Attalah, Ahmed, Yang, Yaqi, Estrada, Chelsea, Yang, Vincent W., He, John C., Mallipattu, Sandeep K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2018
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171275/
https://ncbi.nlm.nih.gov/pubmed/30143559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018030324
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