Krüppel-like factor 6–mediated loss of BCAA catabolism contributes to kidney injury in mice and humans

Altered cellular metabolism in kidney proximal tubule (PT) cells plays a critical role in acute kidney injury (AKI). The transcription factor Krüppel-like factor 6 (KLF6) is rapidly and robustly induced early in the PT after AKI. We found that PT-specific Klf6 knockdown (Klf6(PTKD)) is protective ag...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Piret, Sian E., Guo, Yiqing, Attallah, Ahmed A., Horne, Sylvia J., Zollman, Amy, Owusu, Daniel, Henein, Justina, Sidorenko, Viktoriya S., Revelo, Monica P., Hato, Takashi, Ma’ayan, Avi, He, John Cijiang, Mallipattu, Sandeep K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201852/
https://ncbi.nlm.nih.gov/pubmed/34074766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024414118
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados