Structure-Based Design of A-1293102, a Potent and Selective BCL-X(L) Inhibitor

[Image: see text] BCL-X(L), an antiapoptotic member of the BCL-2 family of proteins, drives tumor survival and maintenance and thus represents a key target for cancer treatment. Herein we report the rational design of a novel series of selective BCL-X(L) inhibitors exemplified by A-1293102. This mol...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Tao, Zhi-Fu, Wang, Xilu, Chen, Jun, Ingram, Justin P., Jin, Sha, Judge, Russell A., Kovar, Peter J., Park, Chang, Sun, Chaohong, Wakefield, Brian D., Zhou, Li, Zhang, Haichao, Elmore, Steven W., Phillips, Darren C., Judd, Andrew S., Leverson, Joel D., Souers, Andrew J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2021
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201748/
https://ncbi.nlm.nih.gov/pubmed/34141086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00162
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