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Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors
The BCL-2/BCL-X(L) inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have...
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| Veröffentlicht in: | Mol Cell Oncol |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4845185/ https://ncbi.nlm.nih.gov/pubmed/27308564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1050155 |
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