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Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors

The BCL-2/BCL-X(L) inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have...

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Bibliografiske detaljer
Udgivet i:Mol Cell Oncol
Hovedforfatter: Leverson, Joel D.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845185/
https://ncbi.nlm.nih.gov/pubmed/27308564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1050155
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