High-Throughput Screen for the Chemical Inhibitors of Antiapoptotic Bcl-2 Family Proteins by Multiplex Flow Cytometry

The human Bcl-2 family includes six antiapoptotic members (Bcl-2, Bcl-B, Bcl-W, Bcl-X(L), Bfl-1, and Mcl-1) and many proapoptotic members, wherein a balance between the two determines cell life or death in many physiological and disease contexts. Elevated expression of various antiapoptotic Bcl-2 me...

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Detalhes bibliográficos
Main Authors: Curpan, Ramona F., Simons, Peter C., Zhai, Dayong, Young, Susan M., Carter, Mark B., Bologa, Cristian G., Oprea, Tudor I., Satterthwait, Arnold C., Reed, John C., Edwards, Bruce S., Sklar, Larry A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182036/
https://ncbi.nlm.nih.gov/pubmed/21561376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2010.0363
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