High-Throughput Screen for the Chemical Inhibitors of Antiapoptotic Bcl-2 Family Proteins by Multiplex Flow Cytometry

The human Bcl-2 family includes six antiapoptotic members (Bcl-2, Bcl-B, Bcl-W, Bcl-X(L), Bfl-1, and Mcl-1) and many proapoptotic members, wherein a balance between the two determines cell life or death in many physiological and disease contexts. Elevated expression of various antiapoptotic Bcl-2 me...

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Détails bibliographiques
Auteurs principaux: Curpan, Ramona F., Simons, Peter C., Zhai, Dayong, Young, Susan M., Carter, Mark B., Bologa, Cristian G., Oprea, Tudor I., Satterthwait, Arnold C., Reed, John C., Edwards, Bruce S., Sklar, Larry A.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2011
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182036/
https://ncbi.nlm.nih.gov/pubmed/21561376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2010.0363
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