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High-Throughput Screen for the Chemical Inhibitors of Antiapoptotic Bcl-2 Family Proteins by Multiplex Flow Cytometry

The human Bcl-2 family includes six antiapoptotic members (Bcl-2, Bcl-B, Bcl-W, Bcl-X(L), Bfl-1, and Mcl-1) and many proapoptotic members, wherein a balance between the two determines cell life or death in many physiological and disease contexts. Elevated expression of various antiapoptotic Bcl-2 me...

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Autors principals: Curpan, Ramona F., Simons, Peter C., Zhai, Dayong, Young, Susan M., Carter, Mark B., Bologa, Cristian G., Oprea, Tudor I., Satterthwait, Arnold C., Reed, John C., Edwards, Bruce S., Sklar, Larry A.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182036/
https://ncbi.nlm.nih.gov/pubmed/21561376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2010.0363
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