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High-Throughput Multiplex Flow Cytometry Screening for Botulinum Neurotoxin Type A Light Chain Protease Inhibitors

Given their medical importance, proteases have been studied by diverse approaches and screened for small molecule protease inhibitors. Here, we present a multiplexed microsphere-based protease assay that uses high-throughput flow cytometry to screen for inhibitors of the light chain protease of botu...

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Detalhes bibliográficos
Main Authors: Saunders, Matthew J., Graves, Steven W., Sklar, Larry A., Oprea, Tudor I., Edwards, Bruce S.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. publishers 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096553/
https://ncbi.nlm.nih.gov/pubmed/20035615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2009.0219
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