Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation

[Image: see text] Remodelin is a putative small molecule inhibitor of the RNA acetyltransferase NAT10 which has shown preclinical efficacy in models of the premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS). Here we evaluate remodelin’s assay interference characteristics and effects...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Shrimp, Jonathan H., Jing, Yihang, Gamage, Supuni Thalalla, Nelson, Kathryn M., Han, Joseph, Bryson, Keri M., Montgomery, David C., Thomas, Justin M., Nance, Kellie D., Sharma, Sunny, Fox, Stephen D., Andressen, Thorkell, Sinclair, Wilson R., Wu, Hong, Allali-Hassani, Abdellah, Senisterra, Guillermo, Vedadi, Masoud, Lafontaine, Denis, Dahlin, Jayme L., Marmorstein, Ronen, Walters, Michael A., Meier, Jordan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201477/
https://ncbi.nlm.nih.gov/pubmed/34141066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00193
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