Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation

[Image: see text] Remodelin is a putative small molecule inhibitor of the RNA acetyltransferase NAT10 which has shown preclinical efficacy in models of the premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS). Here we evaluate remodelin’s assay interference characteristics and effects...

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Publicado en:ACS Med Chem Lett
Autores principales: Shrimp, Jonathan H., Jing, Yihang, Gamage, Supuni Thalalla, Nelson, Kathryn M., Han, Joseph, Bryson, Keri M., Montgomery, David C., Thomas, Justin M., Nance, Kellie D., Sharma, Sunny, Fox, Stephen D., Andressen, Thorkell, Sinclair, Wilson R., Wu, Hong, Allali-Hassani, Abdellah, Senisterra, Guillermo, Vedadi, Masoud, Lafontaine, Denis, Dahlin, Jayme L., Marmorstein, Ronen, Walters, Michael A., Meier, Jordan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2020
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201477/
https://ncbi.nlm.nih.gov/pubmed/34141066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00193
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