Effect of the lysosomotropic agent chloroquine on mTORC1 activation and protein synthesis in human skeletal muscle

BACKGROUND: Previous work in HEK-293 cells demonstrated the importance of amino acid-induced mTORC1 translocation to the lysosomal surface for stimulating mTORC1 kinase activity and protein synthesis. This study tested the conservation of this amino acid sensing mechanism in human skeletal muscle by...

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Detalhes bibliográficos
Publicado no:Nutr Metab (Lond)
Main Authors: Borack, Michael S., Dickinson, Jared M., Fry, Christopher S., Reidy, Paul T., Markofski, Melissa M., Deer, Rachel R., Jennings, Kristofer, Volpi, Elena, Rasmussen, Blake B.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8199655/
https://ncbi.nlm.nih.gov/pubmed/34118944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-021-00585-w
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