Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1‐dependent mechanism in skeletal muscle cells

Amino acid transporters (AATs) provide a link between amino acid availability and mammalian/mechanistic target of rapamycin complex 1 (mTORC1) activation although the direct relationship remains unclear. Previous studies in various cell types have used high insulin concentrations to determine the ro...

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Hlavní autoři: Walker, Dillon K., Drummond, Micah J., Dickinson, Jared M., Borack, Michael S., Jennings, Kristofer, Volpi, Elena, Rasmussen, Blake B.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002227/
https://ncbi.nlm.nih.gov/pubmed/24760501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phy2.238
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