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The Actin ‘A-Triad’s’ Role in Contractile Regulation in Health and Disease

Striated muscle contraction is regulated by Ca(2+)-dependent modulation of myosin cross-bridge binding to F-actin by the thin filament troponin (Tn)-tropomyosin (Tm) complex. In the absence of Ca(2+), Tn binds to actin and constrains Tm to an azimuthal location where it sterically occludes myosin bi...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Schmidt, William, Cammarato, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8198742/
https://ncbi.nlm.nih.gov/pubmed/30770548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276741
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