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The Actin ‘A-Triad’s’ Role in Contractile Regulation in Health and Disease
Striated muscle contraction is regulated by Ca(2+)-dependent modulation of myosin cross-bridge binding to F-actin by the thin filament troponin (Tn)-tropomyosin (Tm) complex. In the absence of Ca(2+), Tn binds to actin and constrains Tm to an azimuthal location where it sterically occludes myosin bi...
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| Published in: | J Physiol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8198742/ https://ncbi.nlm.nih.gov/pubmed/30770548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276741 |
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