Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin. Findings suggest that electrostatic contacts, particularly those between K326, K328, and R147 on actin and tropomyosin, establish an energeti...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Viswanathan, Meera C., Schmidt, William, Rynkiewicz, Michael J., Agarwal, Karuna, Gao, Jian, Katz, Joseph, Lehman, William, Cammarato, Anthony
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902318/
https://ncbi.nlm.nih.gov/pubmed/28903042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.070
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