Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a rare neurodevelopmental disorder characterized by early-onset seizures and severe cognitive, motor, and visual impairments. To date there are no therapies for CDKL5 deficiency disorder (CDD). In view of the severity of the...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Loi, Manuela, Gennaccaro, Laura, Fuchs, Claudia, Trazzi, Stefania, Medici, Giorgio, Galvani, Giuseppe, Mottolese, Nicola, Tassinari, Marianna, Rimondini Giorgini, Roberto, Milelli, Andrea, Ciani, Elisabetta
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8198396/
https://ncbi.nlm.nih.gov/pubmed/34073043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115950
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