Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death

CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. Children affected by CDD display a clinical phenotype characterized by early-onset epilepsy, intellectual disability, motor impairment, and autistic-like features. Although the clin...

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Zapisane w:
Opis bibliograficzny
Wydane w:Aging Dis
Główni autorzy: Gennaccaro, Laura, Fuchs, Claudia, Loi, Manuela, Pizzo, Riccardo, Alvente, Sara, Berteotti, Chiara, Lupori, Leonardo, Sagona, Giulia, Galvani, Giuseppe, Gurgone, Antonia, Raspanti, Alessandra, Medici, Giorgio, Tassinari, Marianna, Trazzi, Stefania, Ren, Elisa, Rimondini, Roberto, Pizzorusso, Tommaso, Zoccoli, Giovanna, Giustetto, Maurizio, Ciani, Elisabetta
Format: Artigo
Język:Inglês
Wydane: JKL International LLC 2021
Hasła przedmiotowe:
Orginal Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139207/
https://ncbi.nlm.nih.gov/pubmed/34094641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2020.0827
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