Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder

BACKGROUND: CDKL5 deficiency disorder (CDD), a severe neurodevelopmental disorder characterized by early onset epilepsy, intellectual disability, and autistic features, is caused by mutations in the CDKL5 gene. Evidence in animal models of CDD showed that absence of CDKL5 negatively affects neuronal...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Galvani, Giuseppe, Mottolese, Nicola, Gennaccaro, Laura, Loi, Manuela, Medici, Giorgio, Tassinari, Marianna, Fuchs, Claudia, Ciani, Elisabetta, Trazzi, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265075/
https://ncbi.nlm.nih.gov/pubmed/34238328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02204-0
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