Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe X-linked neurodevelopmental encephalopathy caused by mutations in the CDKL5 gene and characterized by early-onset epilepsy and intellectual and motor impairments. No cure is currently available for CDD patients, as limited...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Ren, Elisa, Roncacé, Vincenzo, Trazzi, Stefania, Fuchs, Claudia, Medici, Giorgio, Gennaccaro, Laura, Loi, Manuela, Galvani, Giuseppe, Ye, Keqiang, Rimondini, Roberto, Aicardi, Giorgio, Ciani, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503158/
https://ncbi.nlm.nih.gov/pubmed/31114483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00169
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