Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression

The zinc finger transcription factor SALL4 is highly expressed in embryonic stem cells, downregulated in most adult tissues, but reactivated in many aggressive cancers. This unique expression pattern makes SALL4 an attractive therapeutic target. However, whether SALL4 binds DNA directly to regulate...

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Publicat a:Cell Rep
Autors principals: Kong, Nikki R., Bassal, Mahmoud A., Tan, Hong Kee, Kurland, Jesse V., Yong, Kol Jia, Young, John J., Yang, Yang, Li, Fudong, Lee, Jonathan D., Liu, Yue, Wu, Chan-Shuo, Stein, Alicia, Luo, Hongbo R., Silberstein, Leslie E., Bulyk, Martha L., Tenen, Daniel G., Chai, Li
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197658/
https://ncbi.nlm.nih.gov/pubmed/33406418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108574
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