Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression

The zinc finger transcription factor SALL4 is highly expressed in embryonic stem cells, downregulated in most adult tissues, but reactivated in many aggressive cancers. This unique expression pattern makes SALL4 an attractive therapeutic target. However, whether SALL4 binds DNA directly to regulate...

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Pubblicato in:Cell Rep
Autori principali: Kong, Nikki R., Bassal, Mahmoud A., Tan, Hong Kee, Kurland, Jesse V., Yong, Kol Jia, Young, John J., Yang, Yang, Li, Fudong, Lee, Jonathan D., Liu, Yue, Wu, Chan-Shuo, Stein, Alicia, Luo, Hongbo R., Silberstein, Leslie E., Bulyk, Martha L., Tenen, Daniel G., Chai, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197658/
https://ncbi.nlm.nih.gov/pubmed/33406418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108574
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