Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation

Bcl-x pre-mRNA splicing serves as a typical example to study the impact of alternative splicing in the modulation of cell death. Dysregulation of Bcl-x apoptotic isoforms caused by precarious equilibrium splicing is implicated in genesis and development of multiple human diseases, especially cancers...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Dou, Zhihui, Zhao, Dapeng, Chen, Xiaohua, Xu, Caipeng, Jin, Xiaodong, Zhang, Xuetian, Wang, Yupei, Xie, Xiaodong, Li, Qiang, Di, Cuixia, Zhang, Hong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8196531/
https://ncbi.nlm.nih.gov/pubmed/34118966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-02001-w
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