Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation

Bcl-x pre-mRNA splicing serves as a typical example to study the impact of alternative splicing in the modulation of cell death. Dysregulation of Bcl-x apoptotic isoforms caused by precarious equilibrium splicing is implicated in genesis and development of multiple human diseases, especially cancers...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Clin Cancer Res
Prif Awduron: Dou, Zhihui, Zhao, Dapeng, Chen, Xiaohua, Xu, Caipeng, Jin, Xiaodong, Zhang, Xuetian, Wang, Yupei, Xie, Xiaodong, Li, Qiang, Di, Cuixia, Zhang, Hong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2021
Pynciau:
Review
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8196531/
https://ncbi.nlm.nih.gov/pubmed/34118966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-02001-w
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