High amount of transcription factor IRF8 engages AP1-IRF composite elements in enhancers to direct type 1 conventional dendritic cell identity

Development and function of conventional dendritic cell (cDC) subsets, cDC1 and cDC2, depend on transcription factor (TF)s IRF8 and IRF4 respectively. Since IRF8 and IRF4 can each interact with TF BATF3 at AP1-IRF composite elements (AICEs) and with TF PU.1 at Ets-IRF composite elements (EICEs), it...

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Publicat a:Immunity
Autors principals: Kim, Sunkyung, Bagadia, Prachi, Anderson, David A., Liu, Tian-Tian, Huang, Xiao, Theisen, Derek J., O’Connor, Kevin W., Ohara, Ray A., Iwata, Arifumi, Murphy, Theresa L., Murphy, Kenneth M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193644/
https://ncbi.nlm.nih.gov/pubmed/32795402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.07.018
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