Cryptic activation of an Irf8 enhancer governs cDC1 fate specification

Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction are unclear. Here we identified Irf8 enhancers via chromatin profiling of DCs and used CRI...

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Published in:Nat Immunol
Main Authors: Durai, Vivek, Bagadia, Prachi, Granja, Jeffrey M., Satpathy, Ansuman T., Kulkarni, Devesha H., Davidson, Jesse T., Wu, Renee, Patel, Swapneel J., Iwata, Arifumi, Liu, Tiantian, Huang, Xiao, Briseño, Carlos G., Grajales-Reyes, Gary E., Wöhner, Miriam, Tagoh, Hiromi, Kee, Barbara L., Newberry, Rodney D., Busslinger, Meinrad, Chang, Howard Y., Murphy, Theresa L., Murphy, Kenneth M.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707878/
https://ncbi.nlm.nih.gov/pubmed/31406378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0450-x
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