Altered compensatory cytokine signaling underlies the discrepancy between Flt3(–/–) and Flt3l(–/–) mice

The receptor Flt3 and its ligand Flt3L are both critical for dendritic cell (DC) development, but DC deficiency is more severe in Flt3l(−/−) mice than in Flt3(−/−) mice. This has led to speculation that Flt3L binds to another receptor that also supports DC development. However, we found that Flt3L a...

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Pubblicato in:J Exp Med
Autori principali: Durai, Vivek, Bagadia, Prachi, Briseño, Carlos G., Theisen, Derek J., Iwata, Arifumi, Davidson, Jesse T., Gargaro, Marco, Fremont, Daved H., Murphy, Theresa L., Murphy, Kenneth M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940266/
https://ncbi.nlm.nih.gov/pubmed/29572360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171784
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