Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial to avoid permanent organ damage, but delayed diagnosis is common because symptoms usually appear only after strong...

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Publicat a:Nat Commun
Autors principals: Garofalo, Maura, Piccoli, Luca, Romeo, Margherita, Barzago, Maria Monica, Ravasio, Sara, Foglierini, Mathilde, Matkovic, Milos, Sgrignani, Jacopo, De Gasparo, Raoul, Prunotto, Marco, Varani, Luca, Diomede, Luisa, Michielin, Olivier, Lanzavecchia, Antonio, Cavalli, Andrea
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192768/
https://ncbi.nlm.nih.gov/pubmed/34112780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23880-9
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