Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial to avoid permanent organ damage, but delayed diagnosis is common because symptoms usually appear only after strong...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Garofalo, Maura, Piccoli, Luca, Romeo, Margherita, Barzago, Maria Monica, Ravasio, Sara, Foglierini, Mathilde, Matkovic, Milos, Sgrignani, Jacopo, De Gasparo, Raoul, Prunotto, Marco, Varani, Luca, Diomede, Luisa, Michielin, Olivier, Lanzavecchia, Antonio, Cavalli, Andrea
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192768/
https://ncbi.nlm.nih.gov/pubmed/34112780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23880-9
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