Pharmacological and Genetic Blockade of Trpm7 in the Carotid Body Treats Obesity-Induced Hypertension

Obesity increases levels of an adipocyte-produced hormone leptin, which activates the sympathetic nervous system leading to hypertension. We have recently reported that acute leptin infusion induces hypertension acting via the TRPM7 cation channel in the carotid bodies. We hypothesize that this mech...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Shin, Mi-Kyung, Mitrut, Roxana, Gu, Chenjuan, Kim, Lenise J, Yeung, Bonnie H.Y., Lee, Rachel, Pham, Luu, Tang, Wan-Yee, Sham, James S. K., Cui, Honggang, Polotsky, Vsevolod Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192446/
https://ncbi.nlm.nih.gov/pubmed/33993722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16527
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