SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes

Splicing is catalyzed by the spliceosome, a compositionally dynamic complex assembled stepwise on pre-mRNA. We reveal links between splicing machinery components and the intrinsically disordered ciliopathy protein SANS. Pathogenic mutations in SANS/USH1G lead to Usher syndrome—the most common cause...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Yildirim, Adem, Mozaffari-Jovin, Sina, Wallisch, Ann-Kathrin, Schäfer, Jessica, Ludwig, Sebastian E J, Urlaub, Henning, Lührmann, Reinhard, Wolfrum, Uwe
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2021
Konular:
RNA and RNA-protein complexes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191790/
https://ncbi.nlm.nih.gov/pubmed/34023904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab386
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