A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding region comprising an expanded ferredoxin-like fol...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Liu, Sunbin, Mozaffari-Jovin, Sina, Wollenhaupt, Jan, Santos, Karine F, Theuser, Matthias, Dunin-Horkawicz, Stanislaw, Fabrizio, Patrizia, Bujnicki, Janusz M, Lührmann, Reinhard, Wahl, Markus C
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520091/
https://ncbi.nlm.nih.gov/pubmed/26161500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07320
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