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A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
The precise role of the spliceosomal DEAD-box protein Prp28 in higher eukaryotes remains unclear. We show that stable tri-snRNP association during pre-catalytic spliceosomal B complex formation is blocked by a dominant-negative hPrp28 mutant lacking ATPase activity. Complexes formed in the presence...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4935976/ https://ncbi.nlm.nih.gov/pubmed/27377154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11997 |
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