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Total Synthesis of the Spliceosome Modulator Pladienolide B via Asymmetric Alcohol-Mediated syn- and anti-Diastereoselective Carbonyl Crotylation
[Image: see text] Total Synthesis Fueled by Alcohol. The potent spliceosome modulator pladienolide B, which bears 10 stereogenic centers, is prepared in 10 steps (LLS). Asymmetric alcohol-mediated carbonyl crotylations catalyzed by ruthenium and iridium that occur with syn- and anti-diastereoselecti...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8190871/ https://ncbi.nlm.nih.gov/pubmed/33794050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202103845 |
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