CAG repeat instability in embryonic stem cells and derivative spermatogenic cells of transgenic Huntington’s disease monkey

PURPOSE: The expansion of CAG (glutamine; Q) trinucleotide repeats (TNRs) predominantly occurs through male lineage in Huntington’s disease (HD). As a result, offspring will have larger CAG repeats compared to their fathers, which causes an earlier onset of the disease called genetic anticipation. T...

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Vydáno v:J Assist Reprod Genet
Hlavní autoři: Khampang, Sujittra, Parnpai, Rangsun, Mahikul, Wiriya, Easley, Charles A., Cho, In Ki, Chan, Anthony W.S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2021
Témata:
Reproductive Physiology and Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190423/
https://ncbi.nlm.nih.gov/pubmed/33611676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-021-02106-3
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