Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

In the Caenorhabditis elegans germline, thousands of mRNAs are concomitantly expressed with antisense 22G-RNAs, which are loaded into the Argonaute CSR-1. Despite their essential functions for animal fertility and embryonic development, how CSR-1 22G-RNAs are produced remains unknown. Here, we show...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Singh, Meetali, Cornes, Eric, Li, Blaise, Quarato, Piergiuseppe, Bourdon, Loan, Dingli, Florent, Loew, Damarys, Proccacia, Simone, Cecere, Germano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190271/
https://ncbi.nlm.nih.gov/pubmed/34108460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23615-w
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