Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine

The hexameric AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis and initiates cytoplasmic maturation of the large ribosomal subunit by releasing the shuttling maturation factor Rlp24. Drg1 monomers contain two AAA-domains (D1 and D2) that act in a concerted manner. Rlp24 release is i...

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Publicat a:Nat Commun
Autors principals: Prattes, Michael, Grishkovskaya, Irina, Hodirnau, Victor-Valentin, Rössler, Ingrid, Klein, Isabella, Hetzmannseder, Christina, Zisser, Gertrude, Gruber, Christian C., Gruber, Karl, Haselbach, David, Bergler, Helmut
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190095/
https://ncbi.nlm.nih.gov/pubmed/34108481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23854-x
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