The Drug Diazaborine Blocks Ribosome Biogenesis by Inhibiting the AAA-ATPase Drg1

The drug diazaborine is the only known inhibitor of ribosome biogenesis and specifically blocks large subunit formation in eukaryotic cells. However, the target of this drug and the mechanism of inhibition were unknown. Here we identify the AAA-ATPase Drg1 as a target of diazaborine. Inhibitor bindi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Loibl, Mathias, Klein, Isabella, Prattes, Michael, Schmidt, Claudia, Kappel, Lisa, Zisser, Gertrude, Gungl, Anna, Krieger, Elmar, Pertschy, Brigitte, Bergler, Helmut
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2014
विषय:
Enzymology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924260/
https://ncbi.nlm.nih.gov/pubmed/24371142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536110
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