The Drug Diazaborine Blocks Ribosome Biogenesis by Inhibiting the AAA-ATPase Drg1

The drug diazaborine is the only known inhibitor of ribosome biogenesis and specifically blocks large subunit formation in eukaryotic cells. However, the target of this drug and the mechanism of inhibition were unknown. Here we identify the AAA-ATPase Drg1 as a target of diazaborine. Inhibitor bindi...

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Detalhes bibliográficos
Main Authors: Loibl, Mathias, Klein, Isabella, Prattes, Michael, Schmidt, Claudia, Kappel, Lisa, Zisser, Gertrude, Gungl, Anna, Krieger, Elmar, Pertschy, Brigitte, Bergler, Helmut
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924260/
https://ncbi.nlm.nih.gov/pubmed/24371142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536110
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