The Drug Diazaborine Blocks Ribosome Biogenesis by Inhibiting the AAA-ATPase Drg1

The drug diazaborine is the only known inhibitor of ribosome biogenesis and specifically blocks large subunit formation in eukaryotic cells. However, the target of this drug and the mechanism of inhibition were unknown. Here we identify the AAA-ATPase Drg1 as a target of diazaborine. Inhibitor bindi...

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Bibliographische Detailangaben
Hauptverfasser: Loibl, Mathias, Klein, Isabella, Prattes, Michael, Schmidt, Claudia, Kappel, Lisa, Zisser, Gertrude, Gungl, Anna, Krieger, Elmar, Pertschy, Brigitte, Bergler, Helmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924260/
https://ncbi.nlm.nih.gov/pubmed/24371142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536110
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