The Drug Diazaborine Blocks Ribosome Biogenesis by Inhibiting the AAA-ATPase Drg1

The drug diazaborine is the only known inhibitor of ribosome biogenesis and specifically blocks large subunit formation in eukaryotic cells. However, the target of this drug and the mechanism of inhibition were unknown. Here we identify the AAA-ATPase Drg1 as a target of diazaborine. Inhibitor bindi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Loibl, Mathias, Klein, Isabella, Prattes, Michael, Schmidt, Claudia, Kappel, Lisa, Zisser, Gertrude, Gungl, Anna, Krieger, Elmar, Pertschy, Brigitte, Bergler, Helmut
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924260/
https://ncbi.nlm.nih.gov/pubmed/24371142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536110
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker