Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor

Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer’s disease (AD) and other tauopathies, but it is unclear how neuroanatomical connections, spatial proximity, and regional vulnerability contribute. In this study, we seed tau pathology in the br...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Cornblath, Eli J., Li, Howard L., Changolkar, Lakshmi, Zhang, Bin, Brown, Hannah J., Gathagan, Ronald J., Olufemi, Modupe F., Trojanowski, John Q., Bassett, Danielle S., Lee, Virginia M. Y., Henderson, Michael X.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189700/
https://ncbi.nlm.nih.gov/pubmed/34108219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg6677
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