Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth. GSK-3 has two co-expressed isoforms, GSK-3α and GSK-3β. Using conditional gene targeting, we demonstrate that b...

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Detaylı Bibliyografya
Yayımlandı:iScience
Asıl Yazarlar: Steele, Lynette, Mannion, Aarren J., Shaw, Gary, Maclennan, Kenneth A., Cook, Graham P., Rudd, Christopher E., Taylor, Alison
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188550/
https://ncbi.nlm.nih.gov/pubmed/34142056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102555
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