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Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines
In mammalian cells, glycogen synthase kinase-3 (GSK-3) comprises of two homologues, GSK-3α and β, encoded by independent genes, which share similar kinase domains but differ substantially in their termini. Here, we describe the generation of an allelic series of mouse embryonic stem cell (ESC) lines...
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| Publicado no: | Dev Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4485918/ https://ncbi.nlm.nih.gov/pubmed/17543867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2007.04.001 |
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