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Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection
Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth. GSK-3 has two co-expressed isoforms, GSK-3α and GSK-3β. Using conditional gene targeting, we demonstrate that b...
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| Publicat a: | iScience |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8188550/ https://ncbi.nlm.nih.gov/pubmed/34142056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102555 |
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