Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization

Although mutations in the RNA splicing factor SF3B1 are frequent in multiple cancers, their functional effects and therapeutic dependencies are poorly understood. Here we characterize 98 tumors and 12 isogenic cell lines harboring SF3B1 hotspot mutations, identifying hundreds of cryptic 3’ splice si...

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Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Liu, Zhaoqi, Yoshimi, Akihide, Wang, Jiguang, Cho, Hana, Lee, Stanley Chun-Wei, Ki, Michelle, Bitner, Lillian, Chu, Timothy, Shah, Harshal, Liu, Bo, Mato, Anthony R., Ruvolo, Peter, Fabbri, Giulia, Pasqualucci, Laura, Abdel-Wahab, Omar, Rabadan, Raul
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188517/
https://ncbi.nlm.nih.gov/pubmed/32188705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1330
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