Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization

Although mutations in the RNA splicing factor SF3B1 are frequent in multiple cancers, their functional effects and therapeutic dependencies are poorly understood. Here we characterize 98 tumors and 12 isogenic cell lines harboring SF3B1 hotspot mutations, identifying hundreds of cryptic 3’ splice si...

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Publicado en:Cancer Discov
Autores principales: Liu, Zhaoqi, Yoshimi, Akihide, Wang, Jiguang, Cho, Hana, Lee, Stanley Chun-Wei, Ki, Michelle, Bitner, Lillian, Chu, Timothy, Shah, Harshal, Liu, Bo, Mato, Anthony R., Ruvolo, Peter, Fabbri, Giulia, Pasqualucci, Laura, Abdel-Wahab, Omar, Rabadan, Raul
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188517/
https://ncbi.nlm.nih.gov/pubmed/32188705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1330
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