Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization

Although mutations in the RNA splicing factor SF3B1 are frequent in multiple cancers, their functional effects and therapeutic dependencies are poorly understood. Here we characterize 98 tumors and 12 isogenic cell lines harboring SF3B1 hotspot mutations, identifying hundreds of cryptic 3’ splice si...

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Bibliografiset tiedot
Julkaisussa:Cancer Discov
Päätekijät: Liu, Zhaoqi, Yoshimi, Akihide, Wang, Jiguang, Cho, Hana, Lee, Stanley Chun-Wei, Ki, Michelle, Bitner, Lillian, Chu, Timothy, Shah, Harshal, Liu, Bo, Mato, Anthony R., Ruvolo, Peter, Fabbri, Giulia, Pasqualucci, Laura, Abdel-Wahab, Omar, Rabadan, Raul
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188517/
https://ncbi.nlm.nih.gov/pubmed/32188705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1330
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