Mutant SF3B1 promotes AKT- and NF-κB–driven mammary tumorigenesis

Mutations in the core RNA splicing factor SF3B1 are prevalent in leukemias and uveal melanoma, but hotspot SF3B1 mutations are also seen in epithelial malignancies such as breast cancer. Although hotspot mutations in SF3B1 alter hematopoietic differentiation, whether SF3B1 mutations contribute to ep...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Liu, Bo, Liu, Zhaoqi, Chen, Sisi, Ki, Michelle, Erickson, Caroline, Reis-Filho, Jorge S., Durham, Benjamin H., Chang, Qing, de Stanchina, Elisa, Sun, Yiwei, Rabadan, Raul, Abdel-Wahab, Omar, Chandarlapaty, Sarat
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773370/
https://ncbi.nlm.nih.gov/pubmed/33031100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138315
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