Mutant SF3B1 promotes AKT- and NF-κB–driven mammary tumorigenesis

Mutations in the core RNA splicing factor SF3B1 are prevalent in leukemias and uveal melanoma, but hotspot SF3B1 mutations are also seen in epithelial malignancies such as breast cancer. Although hotspot mutations in SF3B1 alter hematopoietic differentiation, whether SF3B1 mutations contribute to ep...

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Vydáno v:J Clin Invest
Hlavní autoři: Liu, Bo, Liu, Zhaoqi, Chen, Sisi, Ki, Michelle, Erickson, Caroline, Reis-Filho, Jorge S., Durham, Benjamin H., Chang, Qing, de Stanchina, Elisa, Sun, Yiwei, Rabadan, Raul, Abdel-Wahab, Omar, Chandarlapaty, Sarat
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773370/
https://ncbi.nlm.nih.gov/pubmed/33031100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138315
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