Mutant SF3B1 promotes AKT- and NF-κB–driven mammary tumorigenesis

Mutations in the core RNA splicing factor SF3B1 are prevalent in leukemias and uveal melanoma, but hotspot SF3B1 mutations are also seen in epithelial malignancies such as breast cancer. Although hotspot mutations in SF3B1 alter hematopoietic differentiation, whether SF3B1 mutations contribute to ep...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Liu, Bo, Liu, Zhaoqi, Chen, Sisi, Ki, Michelle, Erickson, Caroline, Reis-Filho, Jorge S., Durham, Benjamin H., Chang, Qing, de Stanchina, Elisa, Sun, Yiwei, Rabadan, Raul, Abdel-Wahab, Omar, Chandarlapaty, Sarat
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773370/
https://ncbi.nlm.nih.gov/pubmed/33031100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138315
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