Disruptin, a cell-penetrating peptide degrader of EGFR: Cell-Penetrating Peptide in Cancer Therapy

Disruptin is a cell-permeable decoy peptide designed to destabilize activated EGFR, both by inhibiting Hsp90 chaperoning and dissociating the active asymmetric EGFR dimer, which leads to an increase in engagement of activated EGFR with the proteolytic degradation machinery and subsequent loss from t...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Transl Oncol
Asıl Yazarlar: Mehta, Ranjit K., Shukla, Sushmita, Ramanand, Susmita G., Somnay, Vishal, Bridges, Alexander J., Lawrence, Theodore S., Nyati, Mukesh K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press 2021
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187233/
https://ncbi.nlm.nih.gov/pubmed/34107419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101140
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller