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Dual role of inorganic polyphosphate in cardiac myocytes: the importance of polyP chain length for energy metabolism and mPTP activation

We have previously demonstrated that inorganic polyphosphate (polyP) is a potent activator of the mitochondrial permeability transition pore (mPTP) in cardiac myocytes. PolyP depletion protected against Ca(2+)-induced mPTP opening, however it did not prevent and even exacerbated cell death during is...

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Bibliografske podrobnosti
izdano v:Arch Biochem Biophys
Main Authors: Seidlmayer, Lea K., Gomez-Garcia, Maria R., Shiba, Toshikazu, Porter, George A., Pavlov, Evgeny V., Bers, Donald M., Dedkova, Elena N.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186898/
https://ncbi.nlm.nih.gov/pubmed/30571965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2018.12.019
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