Distinct mPTP activation mechanisms in ischaemia–reperfusion: contributions of Ca(2+), ROS, pH, and inorganic polyphosphate

AIMS: The mitochondrial permeability transition pore (mPTP) plays a central role for tissue damage and cell death during ischaemia–reperfusion (I/R). We investigated the contribution of mitochondrial inorganic polyphosphate (polyP), a potent activator of Ca(2+)-induced mPTP opening, towards mPTP act...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Seidlmayer, Lea K., Juettner, Vanessa V., Kettlewell, Sarah, Pavlov, Evgeny V., Blatter, Lothar A., Dedkova, Elena N.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415062/
https://ncbi.nlm.nih.gov/pubmed/25742913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv097
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