Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease

INTRODUCTION: As a key event leading to tubulointerstitial fibrosis in diabetic kidney disease (DKD), epithelial–mesenchymal transition (EMT) has drawn increasing attention from researchers. The antiaging protein Klotho attenuates renal fibrosis in part by inhibiting ERK1/2 signaling in DKD. Early g...

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Bibliografiset tiedot
Julkaisussa:BMJ Open Diabetes Res Care
Päätekijät: Li, Yang, Xue, Meng, Hu, Fang, Jia, Yijie, Zheng, Zongji, Yang, Yanlin, Liu, Xiaolian, Yang, Yuelian, Wang, Yanjing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMJ Publishing Group 2021
Aiheet:
Pathophysiology/Complications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186752/
https://ncbi.nlm.nih.gov/pubmed/34099438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjdrc-2020-002038
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