Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease

INTRODUCTION: As a key event leading to tubulointerstitial fibrosis in diabetic kidney disease (DKD), epithelial–mesenchymal transition (EMT) has drawn increasing attention from researchers. The antiaging protein Klotho attenuates renal fibrosis in part by inhibiting ERK1/2 signaling in DKD. Early g...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:BMJ Open Diabetes Res Care
Auteurs principaux: Li, Yang, Xue, Meng, Hu, Fang, Jia, Yijie, Zheng, Zongji, Yang, Yanlin, Liu, Xiaolian, Yang, Yuelian, Wang, Yanjing
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2021
Sujets:
Pathophysiology/Complications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186752/
https://ncbi.nlm.nih.gov/pubmed/34099438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjdrc-2020-002038
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires